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Jump to Domain:
Aging
Alcohol Abuse
Auditory/Vestibular
Circadian Rhythmicity
Drug Abuse
Emotional Behavior
Epilepsy
Eye/Vision
Growth/Development
Gustation/Olfaction
Histology
Learning/Memory
Metabolism
Movement/Neuromuscular Function
Neuroendocrine
Neuropsychiatric
Pain/Nociception
Social Behavior
Visible Mutants


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ASSAYS

  • Listed below are all assays used to screen mice for abnormal phenotypes, sorted by broad phenotypic categories (domains). The same assay may be listed under multiple domains.
  • "Protocol Links" (the last three columns) provide links to protocol information for that assay as it is performed at each mutagenesis center (NU=Northwestern University, TMGC=Tennessee Mouse Genome Consortium, JAX-NMF=The Jackson Laboratory). If no text exists for a particular center, then that center does not have a standard protocol for that assay.

Phenotypic Domain Associated Assay(s) Protocol Links
Aging
(return to top)
Morbidity and mortality
TMGC
Light/Dark exploration
TMGC
Open field test (OFT)
TMGC
Tail suspension test
TMGC
Eye histology
TMGC
Eye weight
TMGC
Neurodevelopmental behavior battery
TMGC
Fear conditioning test
TMGC
Y-maze for spontaneous alternation
TMGC
Acoustic startle response (ASR)
TMGC
Prepulse inhibition of startle (PPI)
TMGC
Hot plate test
TMGC
Buried food test
TMGC
Brain weight
TMGC
Adrenal histology
TMGC
Brain/spinal cord histology
TMGC
Adrenal weight
TMGC
Alcohol Abuse
(return to top)
Alcohol-influenced activity
TMGC
Core body temperature
TMGC
Corticosterone hormone assay
TMGC
Ethanol metabolism measure (BAC)
TMGC
Intoxication rating scale
TMGC
Rotarod performance
TMGC
Two-bottle ethanol-choice test
TMGC
Elevated plus maze (EPM)
TMGC
Auditory/Vestibular
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Auditory brain stem response (ABR)
TMGC JAX-NMF
Acoustic startle response (ASR)
TMGC JAX-NMF
Overt movement/posture NU TMGC JAX-NMF
Distortion product otoacoustic emissions (DPOAE)
TMGC
Circadian Rhythmicity
(return to top)
Circadian locomotor activity rhythm NU

Drug Abuse
(return to top)
Cocaine-influenced activity NU TMGC
Cocaine sensitization
TMGC
Food neophobia
TMGC
Locomotion in a novel environment
TMGC
Novel object interaction
TMGC
Place preference to cocaine
TMGC
Emotional Behavior
(return to top)
Open field test (OFT) NU TMGC
Tail suspension test
TMGC
Corticosterone hormone assay NU TMGC
Elevated plus maze (EPM) NU TMGC
Fear conditioning test NU TMGC
Thyroid-stimulating hormone (TSH) assay NU

Food neophobia
TMGC
Locomotion in a novel environment
TMGC
Novel object interaction
TMGC
Light/Dark exploration
TMGC
Epilepsy
(return to top)
Electroconvulsive threshold (ECT)

JAX-NMF
Electroencephalogram (EEG)

JAX-NMF
Eye/Vision
(return to top)
Eye histology NU TMGC JAX-NMF
Electroretinogram (ERG) NU TMGC JAX-NMF
Indirect ophthalmoscopy
TMGC JAX-NMF
Slit lamp eye exam
TMGC JAX-NMF
Eye morphology NU TMGC JAX-NMF
Fundus photography NU TMGC
Eye weight
TMGC
Growth/Development
(return to top)
Anogenital distance
TMGC
Body weight NU TMGC JAX-NMF
Brain/spinal cord histology

JAX-NMF
Coat/Fur
TMGC JAX-NMF
Skeletal NU TMGC JAX-NMF
Eye morphology NU
JAX-NMF
Brain weight
TMGC
Perinatal lethality
TMGC
Embryonic lethality
TMGC
Postnatal lethality NU TMGC
Morbidity and mortality
TMGC
Neurodevelopmental behavior battery
TMGC
Adrenal weight
TMGC
Gustation/Olfaction
(return to top)
Two-bottle choice taste test

JAX-NMF
Two-bottle ethanol-choice test
TMGC
Buried food test
TMGC
Histology
(return to top)
Eye histology NU TMGC JAX-NMF
Adrenal histology
TMGC JAX-NMF
Brain/spinal cord histology
TMGC JAX-NMF
Brain weight
TMGC
Learning/Memory
(return to top)
Fear conditioning test NU TMGC
Novel object interaction
TMGC
Y-maze for spontaneous alternation
TMGC
Metabolism
(return to top)
Body weight NU
JAX-NMF
Core body temperature
TMGC
Ethanol metabolism measure (BAC)
TMGC
Movement/Neuromuscular Function
(return to top)
Overt movement/posture NU TMGC JAX-NMF
Grip strength

JAX-NMF
Skeletal NU TMGC JAX-NMF
Rotarod performance
TMGC
Open field test (OFT) NU TMGC
Alcohol-influenced activity
TMGC
Cocaine-influenced activity
TMGC
Locomotion in a novel environment
TMGC
Neurodevelopmental behavior battery
TMGC
Serum creatine kinase assay

JAX-NMF
Neuroendocrine
(return to top)
Adrenal histology
TMGC JAX-NMF
Corticosterone hormone assay NU TMGC
Thyroid-stimulating hormone (TSH) assay NU

Adrenal weight
TMGC
Neuropsychiatric
(return to top)
Acoustic startle response (ASR)
TMGC JAX-NMF
Prepulse inhibition of startle (PPI)
TMGC
Pain/Nociception
(return to top)
Hot plate test
TMGC
Social Behavior
(return to top)
Opposite sex investigation test
TMGC
Anogenital distance
TMGC
Same sex intruder test
TMGC
Scent marking test
TMGC
Social habituation/dishabituation test
TMGC
Visible Mutants
(return to top)
Overt movement/posture NU TMGC JAX-NMF
Body weight

JAX-NMF
Coat/Fur NU TMGC JAX-NMF
Skeletal NU TMGC JAX-NMF
Eye morphology NU TMGC JAX-NMF
Perinatal lethality
TMGC
Embryonic lethality
TMGC
Postnatal lethality NU TMGC