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| MUTANT LINE 116TNE |
Contact TMGC for ordering information
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| Synopsis: |
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Reduced locomotor stimulation in response to cocaine. |
| Detailed Phenotype Description: |
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This autosomal recessive mutation (tmgc35), linked to distal Chr 15, was detected in the progeny of C57BL/6JRn males given a single dose of 200 mg/kg ENU. A total of 15, 116 TNE mice were tested and compared to 144 mice of related pedigrees. Testing revealed that mice of this pedigree appeared to be relatively insensitive to the locomotor stimulating effect of cocaine (10 mg/kg), and also showed much reduced sensitization to this drug . The 116 TNE pedigree is -1.96 std. deviations below the mean following the first cocaine injection (LOC_CHCL_ADIST_3) and -1.68 SD below the population mean following the second sensitizing injection (SEN_CHCL_ADIST_4). In both cases all mice of this pedigree showed very little variability in their response to cocaine.
Detailed data sheet
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| Abnormal Assays: | Domain(s): |
| Cocaine sensitization (view protocol) |
Drug Abuse
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| Cocaine-influenced activity (view protocol) |
Drug Abuse,
Movement/Neuromuscular Function
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MUTANT LINE INFORMATION |
Mutant Line Name
| 116TNE (view more detail at Mutagenesis Center) |
| Gene Symbol |
tmgc43
(view more info on gene)
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| Gene Name |
Tennessee Mouse Genome Consortium 43 |
| Allele Symbol |
tmgc43 |
| Allele Name |
Tennessee Mouse Genome Consortium 43 |
| MGI ID |
MGI:3511453 (view MGI record) |
| Originating Mutagenesis Center |
Tennessee Mouse Genome Consortium (contact for ordering information) |
| Mutation Type |
chemically induced mutation (CI)
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| Strain Designation |
STOCK 116TNE |
| Data Sheet |
view data sheet |
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HERITABILITY AND MAPPING INFORMATION |
| Background Strain |
Mixed, noninbred |
| Mode of Inheritance |
Recessive |
| Heritability |
Proven (Segregation In Progress, view detail) |
| Chromosome Location |
15 |
| Mapping Interval |
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| Identified Mutation |
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STATUS INFORMATION |
| Availability |
- Live mice (LM)
- Cryopreserved embryos (EM)
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| Confirmation Date |
29-Nov-2004 |
| Availability Date |
01-Mar-2005 |
| Off-Shelf Date |
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| Line History Comments |
(1) 116TNE have been requested and distributed to investigators. |
