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| MUTANT LINE 009TNP |
Contact TMGC for ordering information
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| Synopsis: |
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Wide frequency hearing loss with circling behavior |
| Detailed Phenotype Description: |
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This autosomal recessive mutation (tmgc44), linked to mid Chr7, was detected in the progeny of non-inbred D7R75M males given one dose of 125 mg/kg ENU. This Mutant displayed circling behavior, suggesting vestibular defects, but the vestibular involvement is unconfirmed as yet. We have tested a total of 15-17 mice in only 2 generations of the 9TNP pedigree. This pedigree shows significant hearing loss at all frequencies. To compare to all other TNP pedigrees (n=28-53 at each stimulus), ABR thresholds of 9TNP are elevated significantly at click (3.9 x SD), 8 kHz (3.7 x SD), 16 kHz (6.7 x SD) and 32 kHz (1.9 x SD). Wide-range frequency hearing loss is characteristic of congenital deafness in humans. Thus this mutant could provide a model for such a common disorder. Due to breeding problems this mutant is not available live and must be recovered from frozen sperm upon request.
Detailed data sheet
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| Abnormal Assays: | Domain(s): |
| Auditory brain stem response (ABR) (view protocol) |
Auditory/Vestibular
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| Overt movement/posture (view protocol) |
Visible Mutants,
Movement/Neuromuscular Function
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MUTANT LINE INFORMATION |
Mutant Line Name
| 009TNP (view more detail at Mutagenesis Center) |
| Gene Symbol |
tmgc44
(view more info on gene)
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| Gene Name |
Tennessee Mouse Genome Consortium 44 |
| Allele Symbol |
tmgc44 |
| Allele Name |
Tennessee Mouse Genome Consortium 44 |
| MGI ID |
MGI:3589238 (view MGI record) |
| Originating Mutagenesis Center |
Tennessee Mouse Genome Consortium (contact for ordering information) |
| Mutation Type |
chemically induced mutation (CI)
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| Strain Designation |
STOCK 009TNP |
| Data Sheet |
view data sheet |
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HERITABILITY AND MAPPING INFORMATION |
| Background Strain |
Mixed, noninbred |
| Mode of Inheritance |
Recessive |
| Heritability |
Proven (Segregation In Progress, view detail) |
| Chromosome Location |
7 |
| Mapping Interval |
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| Identified Mutation |
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STATUS INFORMATION |
| Availability |
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| Confirmation Date |
18-Jan-2005 |
| Availability Date |
22-Aug-2005 |
| Off-Shelf Date |
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| Line History Comments |
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